Shu-ichi Ikeda Selected Research

Diflunisal (Dolobid)

1/2015	Safety and efficacy of long-term diflunisal administration in hereditary transthyretin (ATTR) amyloidosis.
12/2013	Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial.
6/2012	The Diflunisal Trial: study accrual and drug tolerance.
1/2008	Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses.
12/2006	Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis.

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Shu-ichi Ikeda Research Topics

Disease

27	Amyloidosis 04/2016 - 05/2002
21	Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy) 12/2013 - 11/2002
15	Immunoglobulin Light-chain Amyloidosis 01/2015 - 01/2003
10	Amyloid Plaque 12/2011 - 12/2002
9	Rheumatoid Arthritis 01/2011 - 05/2002
7	Polyneuropathies (Polyneuropathy) 01/2015 - 03/2002
7	Citrullinemia 08/2013 - 10/2003
5	Alzheimer Disease (Alzheimer's Disease) 01/2013 - 08/2003
5	Parkinson Disease (Parkinson's Disease) 06/2012 - 05/2003
4	Carpal Tunnel Syndrome 11/2014 - 03/2003
4	Brain Diseases (Brain Disorder) 11/2010 - 01/2004
4	Thymoma (Thymic Carcinoma) 11/2006 - 03/2004
4	Myasthenia Gravis 11/2006 - 03/2004
3	Inborn Genetic Diseases (Disease, Hereditary) 12/2015 - 03/2013
3	Anti-N-Methyl-D-Aspartate Receptor Encephalitis 01/2015 - 01/2013
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2014 - 06/2012
3	Hemorrhage 09/2014 - 06/2004
3	Disease Progression 02/2013 - 01/2007
3	Cardiomyopathies (Cardiomyopathy) 12/2012 - 03/2003
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 05/2011 - 06/2005
3	Adult-onset citrullinemia type 2 11/2010 - 03/2005
3	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 01/2008 - 09/2004
3	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 01/2007 - 06/2004
2	Encephalitis (Encephalitis, Rasmussen) 01/2015 - 01/2014
2	Ovarian Teratoma 01/2014 - 01/2013
2	Huntington Disease (Huntington's Disease) 01/2013 - 06/2012
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 06/2012 - 03/2009
2	Proteostasis Deficiencies 06/2012 - 01/2008
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2012 - 08/2011
2	Dementia (Dementias) 06/2012 - 08/2003
2	Proteinuria 01/2011 - 01/2003
2	Leukoencephalopathies 01/2011 - 09/2003
2	Adenocarcinoma 01/2011 - 01/2004
2	Hypertension (High Blood Pressure) 04/2010 - 10/2007
2	Hepatic Encephalopathy 01/2010 - 04/2004
2	Peritonitis 01/2010 - 03/2003
2	Neck Pain (Cervicalgia) 01/2010 - 04/2002
2	Peripheral Nervous System Diseases (PNS Diseases) 11/2009 - 08/2008
2	Lymphadenopathy 06/2008 - 02/2004
2	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 06/2008 - 06/2004
2	Multiple Sclerosis 10/2007 - 08/2003
2	Necrosis 01/2007 - 12/2003
2	Pancreatitis 01/2007 - 09/2003
2	Hyperferritinemia 01/2007 - 06/2004
2	Lymphoma (Lymphomas) 05/2006 - 02/2004
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 09/2005 - 10/2003

Drug/Important Bio-Agent (IBA)

29	Amyloid (Amyloid Fibrils)IBA 12/2015 - 03/2003
27	Prealbumin (Transthyretin)IBA 04/2016 - 03/2002
16	Proteins (Proteins, Gene)FDA Link 12/2015 - 01/2003
14	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2013 - 05/2002
7	Pharmaceutical PreparationsIBA 01/2015 - 05/2002
7	Melphalan (Alkeran)FDA LinkGeneric 01/2014 - 01/2003
7	Prednisolone (Predate)FDA LinkGeneric 11/2012 - 05/2002
6	AA amyloidosisIBA 06/2012 - 05/2002
5	Diflunisal (Dolobid)FDA Link 01/2015 - 12/2006
5	Intravenous Immunoglobulins (IVIG)FDA Link 01/2012 - 09/2003
5	Immunoglobulins (Immunoglobulin)IBA 06/2008 - 05/2004
5	EnzymesIBA 01/2007 - 10/2003
4	AutoantibodiesIBA 01/2015 - 01/2004
4	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 01/2015 - 12/2004
4	Tacrolimus (Prograf)FDA LinkGeneric 11/2012 - 06/2004
4	DNA (Deoxyribonucleic Acid)IBA 11/2011 - 10/2003
4	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2011 - 01/2003
4	Vincristine (Oncovin)FDA LinkGeneric 01/2011 - 01/2003
4	Dexamethasone (Maxidex)FDA LinkGeneric 01/2011 - 01/2003
4	CitrullineIBA 11/2010 - 04/2004
4	AmmoniaIBA 11/2010 - 04/2004
3	Immunoglobulin G (IgG)IBA 01/2015 - 01/2007
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2015 - 01/2013
3	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 06/2012 - 04/2002
3	Methylprednisolone FDA LinkGeneric 01/2012 - 08/2003
3	Urea (Carbamide)FDA LinkGeneric 11/2010 - 01/2007
3	Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA 01/2007 - 10/2003
3	CytokinesIBA 10/2006 - 06/2004
3	Immunoglobulin M (IgM)IBA 07/2006 - 06/2004
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2006 - 12/2003
2	citrinIBA 08/2015 - 10/2003
2	SteroidsIBA 01/2015 - 10/2007
2	Superoxide Dismutase-1IBA 10/2014 - 06/2012
2	Pyruvic Acid (Pyruvate)IBA 08/2013 - 11/2010
2	SodiumIBA 08/2013 - 11/2010
2	Arginine (L-Arginine)FDA Link 08/2013 - 11/2010
2	AntibodiesIBA 01/2013 - 09/2005
2	Familial apoceruloplasmin deficiencyIBA 03/2012 - 12/2002
2	Matrix Metalloproteinases (MMPs)IBA 05/2011 - 06/2007
2	DystrophinIBA 05/2011 - 06/2005
2	Amyloidogenic ProteinsIBA 02/2011 - 02/2008
2	Methotrexate (Mexate)FDA LinkGeneric 01/2011 - 02/2004
2	CarbohydratesIBA 11/2010 - 01/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2010 - 06/2004
2	Rituximab (Mabthera)FDA Link 01/2010 - 07/2006
2	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 06/2008 - 05/2006
2	sulfate-3-glucuronyl paraglobosideIBA 07/2006 - 05/2006

Therapy/Procedure

22	Therapeutics 01/2014 - 05/2002
11	Liver Transplantation 01/2015 - 03/2003
11	Drug Therapy (Chemotherapy) 02/2013 - 01/2003
3	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 02/2008 - 01/2003
2	Aftercare (After-Treatment) 01/2015 - 01/2006
2	Stem Cell Transplantation 01/2014 - 06/2004
2	Thymectomy 01/2006 - 03/2004